MidAmerica Productions concerts have showcased choral groups singing oratorios with talented conductors, full orchestra, and professional soloists; individual instrumental and choral groups performing as part of the Ensemble Spotlight Series; and solo recitals. Diverse programs have included Madrigal Festivals, Vocal Jazz Festivals, National Wind Ensemble, National Festival Youth Orchestra, and Sweet Adelines. Among the renowned guest conductors who have led MidAmerica’s concerts are Sir John Rutter CBE (who has conducted more than 135 concerts in Stern Auditorium/Perelman Stage at Carnegie Hall), Lukas Foss, Helmuth Rilling, H. Robert Reynolds, JoAnne Falletta, Michael Morgan, and Jonathan Willcocks. More than 900 conductors have conducted on MidAmerica's series in New York and abroad, sharing the stage with 1500 solo artists from the world’s greatest opera companies and concert stages, and 4700 choral ensembles from the U.S. and abroad. There have been 174 youth and collegiate orchestras as well as 146 youth and collegiate bands, jazz bands, and wind ensembles.

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Over the years, MidAmerica has commissioned new works and presented numerous premieres in Stern Auditorium/Perelman Stage at Carnegie Hall and Avery Fisher Hall. World premieres have included Dinos Constantinides’ Byron’s Greece, Hymn to the Human Spirit, and Midnight Fantasy II for wind ensemble; Sir John Rutter’s Cantate Domino, Distant Land, Magnificat, and Mass of the Children; and John Leavitt’s A Christmas Garland. U.S. premieres have featured new and older works such as Mozart’s Die Schuldigkeit des ersten Gebots, Reimann’s Concerto for Violin and Cello, Tchaikovsky’s Ode to Joy, Mikis Theodorakis’ Electra and Rhapsody for Cello and Orchestra, and René Clausen’s Hellas: In the Name of Freedom.  In 2015, John Rutter conducted the New York premiere of Canticles of Creation, followed in 2018 by the Carnegie Hall premiere of his work Visions. In 2023, he returned to lead the New York premiere of Taranto: A Cathedral Triptych, and in 2024, his latest work, Celebration, received its world premiere with MidAmerica Productions.

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In addition to its Stern Auditorium/Perelman Stage series, MidAmerica Productions has presented nearly 400 chamber music concerts in Weill Recital Hall at Carnegie Hall since 1989. World-class soloists, chamber ensembles, and members of orchestras such as the New York Philharmonic, The Metropolitan Opera Orchestra, The Philadelphia Orchestra, The Atlanta Symphony, and the Los Angeles Philharmonic have appeared on MidAmerica’s chamber music series.